Dscam pin code, [5] In humans, DSCAM refers to a gene that encodes one of several protein isoforms. (1998) isolated and characterized a novel gene, DSCAM (Down syndrome cell adhesion molecule), which was found by homology searches to be a member of the immunoglobulin superfamily that represents a new class of neural cell adhesion molecules. . [6] Down syndrome (DS), caused by trisomy 21, is the most common birth defect associated with intellectual disability. Figure 1 The domain structures of human DSCAM and Drosophila Dscam are compared. Find diseases associated with this biological target and compounds tested against it in bioassay experiments. DSCAM was found to be expressed largely in the developing nervous system. 3. Genetic and biochemical studies have shown th … Jan 1, 2024 · Down Syndrome Cell Adhesion Molecule. DSCAM is defined as a cell adhesion molecule encoded by the Dscam gene, which plays a crucial role in neural circuit formation through homophilic interactions, allowing for specific synaptic connections and the recognition and repulsion of neurons expressing the same isoforms. Down Syndrome Cell Adhesion Molecule (DSCAM) is an HSA21 axon guidance molecule involved in the development of the nervous system (2). In Drosophila, Dscam functions as an axon guidance receptor regulating targeting and branching. Jan 1, 2009 · Based on these observations, the protein was dubbed the Down syndrome cell adhesion molecule (DSCAM, pronounced ∪dē-es-kam) (Yamakawa et al. Since this initial report, the DSCAM family has grown with the discovery of paralogs and homologs in mammals, fish, birds, insects, sea urchins, crustaceans, and mollusks. Nov 18, 2019 · Yamakawa et al. Percentage identities of the compared domains are indicated in numbers between dashed lines. da dendrites expressing a form of Dscam in which the cytoplasmic domain was replaced with GFP formed stable bridges. Gene target information for DSCAM - DS cell adhesion molecule (human). A large number of Dscam isoforms are produced by alternative splicing on multiple alternative exon clusters (exons 4, 6, 9 and 17). Diseases associated with DSCAM include Developmental Malformations-Deafness-Dystonia Syndrome and Hirschsprung Disease 1. The data suggest that the dendrites of da neurons convert an initial Dscam-dependent cell-surface interaction into a repulsive response, which leads to dendrite separation and receptive field elaboration. 1998). 2-22. UniProt is the world's leading high-quality, comprehensive and freely accessible resource of protein sequence and functional information. In Drosophila, alternative splicing of the Dscam gene results in over 38,000 isoforms, while in vertebrates, related Jan 4, 2019 · DSCAM Code , Dscam code, Dscam code online,Where to buy DSCAM code,Dscam for 1 year Pagariya 5050 DSCAM,Wezone 8009 DSCAM , Clan 8007 DSCAM,Champion 4000 HD DSCAM,China Set top box DSCAM, May 1, 2024 · In this review, we aim to delineate the distinct molecules that interact with DSCAM and their specific roles within the biological landscapes of Drosophila and vertebrates. Jul 30, 2004 · The Down syndrome cell adhesion molecule (DSCAM) is a member of the immunoglobulin superfamily that maps to a Down syndrome region of chromosome 21q22. DSCAM plays a crucial role in the development of DS: it is expressed in the developing nervous system, with the Jan 14, 2026 · DSCAM (DS Cell Adhesion Molecule) is a Protein Coding gene. By integrating these comparative insights, we aim to elucidate the multifunctional nature of DSCAM, particularly its capacity to facilitate or deter intercellular adhesion. DSCAM and Dscam are both abbreviations for Down syndrome cell adhesion molecule.


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